Recombinant Human Angiopoietin-related Protein 7, His (HEK293-expressed) 調(diào)控血管生成，通過Wnt信號通路促進(jìn)人造血干細(xì)胞和祖細(xì)胞的增殖。Angiopoietin-related Protein 7是一種促炎因子，通過P38 MAPK信號通路誘導(dǎo)巨噬細(xì)胞的炎癥反應(yīng)。
Synonyms
rHuAngiopoietin-related Protein 7, His; ANGPTL7; Angiopoietin-related Protein 7 ; 重組人血管生成素樣蛋白7
Species
HumanSource
HEK 293 Accession
O43827 Gene ID
10218 Molecular Weight
45-55 kDa AA Sequence
QKLSKHKTPA QPQLKAANCC EEVKELKAQV ANLSSLLSEL NKKQERDWVS VVMQVMELES NSKRMESRLT DAESKYSEMN NQIDIMQLQA AQTVTQTSAD AIYDCSSLYQ KNYRISGVYK LPPDDFLGSP ELEVFCDMET SGGGWTIIQR RKSGLVSFYR DWKQYKQGFG SIRGDFWLGN EHIHRLSRQP TRLRVEMEDW EGNLRYAEYS HFVLGNELNS YRLFLGNYTG NVGNDALQYH NNTAFSTKDK DNDNCLDKCA QLRKGGYWYN CCTDSNLNGV YYRLGEHNKH LDGITWYGWH GSTYSLKRVE MKIRPEDFKP HHHHHHHHHH Biological Activity
Data is not available. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Angiopoietin-related Protein 7, His (HEK293-expressed) (rHuAngiopoietin-related Protein 7, His) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human Angiopoietin-related Protein 7, His (HEK293-expressed) (rHuAngiopoietin-related Protein 7, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Human Angiopoietin-related Protein 7 is the least explored member of the Angptl family. It was originally cloned from human corneal cells and named corneaderived transcript 6. Angiopoietin-related Protein 7 can modify the expression of extracellular matrix proteins in human melanoma cells and trabecular meshwork cells, indicating that it functions as a corneal morphogen and can regulate intraocular pressure. |
