Synonyms
rHuAldehyde Dehydrogenase 1-A2, His ; ALDH-1A2; Aldehyde Dehydrogenase 1-A2 ; 重組人醛脫氫酶 1-A2，His
Species
HumanSource
E. coli Accession
O94788 Gene ID
8854 Molecular Weight
50-65 kDa AA Sequence
HHHHHHMTSS KIEMPGEVKA DPAALMASLH LLPSPTPNLE IKYTKIFINN EWQNSESGRV FPVYNPATGE QVCEVQEADK ADIDKAVQAA RLAFSLGSVW RRMDASERGR LLDKLADLVE RDRAVLATME SLNGGKPFLQ AFYVDLQGVI KTFRYYAGWA DKIHGMTIPV DGDYFTFTRH EPIGVCGQII PWNFPLLMFA WKIAPALCCG NTVVIKPAEQ TPLSALYMGA LIKEAGFPPG VINILPGYGP TAGAAIASHI GIDKIAFTGS TEVGKLIQEA AGRSNLKRVT LELGGKSPNI IFADADLDYA VEQAHQGVFF NQGQCCTAGS RIFVEESIYE EFVRRSVERA KRRVVGSPFD PTTEQGPQID KKQYNKILEL IQSGVAEGAK LECGGKGLGR KGFFIEPTVF SNVTDDMRIA KEEIFGPVQE ILRFKTMDEV IERANNSDFG LVAAVFTNDI NKALTVSSAM QAGTVWINCY NALNAQSPFG GFKMSGNGRE MGEFGLREYS EVKTVTVKIP QKNS Biological Activity
Data is not available. Appearance
Solution Formulation
Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 150 mM NaCl, 20% Glycerol, pH 8.0. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
N/A Storage & Stability
Recombinant Human Aldehyde Dehydrogenase 1-A2, His (rHuAldehyde Dehydrogenase 1-A2, His ) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Shipping with dry ice. Background
The aldehyde dehydrogenase 1 (ALDH1) family comprises major enzymes that produce retinoic acid (RA) via the oxidation of all-trans retinal and 9-cis-retinal. The ALDH1A subfamily consists of three members, ALDH1A1, ALDH1A2, and ALDH1A3. ALDH1A2 is a rate-limiting enzyme involved in the cellular synthesis of retinoic acid, which has prodifferentiation properties. ALDH1A2 is a candidate tumor suppressor. Low ALDH1A2 expression was associated with an unfavorable prognosis in head and neck squamous cell carcinoma. ALDH1A2 suppresses epithelial ovarian cancer cell proliferation and migration by downregulating STAT3[1][2]. |
