Recombinant Human PD-1, Fc Chimera (CHO-expressed) 當與T細胞受體的配體PD-L1或PD-L2結(jié)合時，抑制T細胞受體的激活信號。
Synonyms
rHuPD-1, Fc Chimera; PD1; CD279; PDCD1 ; 重組人PD-1, Fc Chimera (CHO 表達)
Species
HumanSource
CHO Accession
Q15116 Gene ID
5133 Molecular Weight
60-65 kDa AA Sequence
LDSPDRPWNP PTFSPALLVV TEGDNATFTC SFSNTSESFV LNWYRMSPSN QTDKLAAFPE DRSQPGQDCR FRVTQLPNGR DFHMSVVRAR RNDSGTYLCG AISLAPKAQI KESLRAELRV TERRAEVPTA HPSPSPRPAG QFQ Biological Activity
1 μg/mL (100 μL/well) of immoblized recombinant human PD-L1/B7-H1-Fc can bind human Biotin-PD-1-Fc with a linear range of 0.1-1 μg/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human PD-1, Fc Chimera (CHO-expressed) (rHuPD-1, Fc Chimera) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human PD-1, Fc Chimera (CHO-expressed) (rHuPD-1, Fc Chimera) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Programmed death-1 (PD-1) is a receptor on T cells that has been shown to suppress activating signals from the T cell receptor when bound by either of its ligands, programmed death-ligand 1 (PD-L1) or PD-L2. When PD-1 expressing T cells contact cells expressing its ligands, functional activities in response to antigenic stimuli, including proliferation, cytokine secretion, and cytotoxicity are reduced[1]. |
