Recombinant Human Tyrosine kinase receptor A (HEK293-expressed) 是神經(jīng)營(yíng)養(yǎng)素、神經(jīng)生長(zhǎng)因子的高親和力催化受體，調(diào)節(jié)神經(jīng)生長(zhǎng)因子的多種作用，包括神經(jīng)元分化和避免程序性細(xì)胞死亡。
Synonyms
rHuTrkA; NTRK1; MTC; TRK ; 重組人酪氨酸激酶受體 A (HEK293細(xì)胞表達(dá))
Species
HumanSource
HEK 293 Accession
P04629 Gene ID
4914 Molecular Weight
65-85 kDa AA Sequence
APCPDACCPH GSSGLRCTRD GALDSLHHLP GAENLTELYI ENQQHLQHLE LRDLRGLGEL RNLTIVKSGL RFVAPDAFHF TPRLSRLNLS FNALESLSWK TVQGLSLQEL VLSGNPLHCS CALRWLQRWE EEGLGGVPEQ KLQCHGQGPL AHMPNASCGV PTLKVQVPNA SVDVGDDVLL RCQVEGRGLE QAGWILTELE QSATVMKSGG LPSLGLTLAN VTSDLNRKNV TC Biological Activity
The ED50 is <1 μg/mL as measured by TF-1 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Tyrosine kinase receptor A (HEK293-expressed) (rHuTrkA) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Tyrosine kinase receptor A (HEK293-expressed) (rHuTrkA) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Tyrosine kinase receptor A (TrkA) is the high affinity catalytic receptor for the neurotrophin, nerve growth factor (NGF), and mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death. TrkA is originally cloned from a colon tumor; the cancer occurred via a translocation, which results in the activation of the TrkA kinase domain[1][2]. |
