Recombinant Human Transforming Growth Factor alpha (CHO-expressed) 是一種有效的血管生成介質(zhì)和有絲分裂多肽。
Synonyms
rHuTGF-α; ETGF; TGFA ; 重組人轉(zhuǎn)化生長因子 (CHO細(xì)胞表達(dá))
Species
HumanSource
CHO Accession
P01135 Gene ID
7039 Molecular Weight
8-10 kDa AA Sequence
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG ARCEHADLLA Biological Activity
The ED50 is <0.4 ng/mL as measured by 3T3 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Transforming Growth Factor alpha (CHO-expressed) (rHuTGF-α) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Transforming Growth Factor alpha (CHO-expressed) (rHuTGF-α) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Transforming growth factors (TGF's) are polypeptides that can confer phenotypic transformation to several normal cells. TGF-α binds to the receptor for epidermal growth factor (EGF) and has been isolated from a variety of tumor cells. TGF-α is synthesized in embryos during early fetal development, in several virally transformed cells, and in a large variety of human tumors[1]. TGF-α is a member of the epidermal growth factor family of mitogens and associated with progression of transformed properties in human colon cancer cells[2]. |
