Recombinant Mouse Macrophage Inflammatory Protein-3 beta/CCL19 一種趨化性細(xì)胞因子，能夠與 CCR7 結(jié)合，調(diào)節(jié)炎癥反應(yīng)。
Synonyms
rMuMIP-3β/CCL19; C-C motif chemokine 19; SCYA19 ; 重組小鼠巨噬細(xì)胞炎性蛋白-3 beta/CCL19
Species
MouseSource
E. coli Accession
O70460 Gene ID
24047 Molecular Weight
Approximately 9.2 kDa AA Sequence
GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS Biological Activity
Full biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10-100 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Mouse Macrophage Inflammatory Protein-3 beta/CCL19 (rMuMIP-3β/CCL19) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Mouse Macrophage Inflammatory Protein-3 beta/CCL19 (rMuMIP-3β/CCL19) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Macrophage Inflammatory Protein-3 beta/CCL19 is a chemokine that binds to CCR7, modulates the inflammatory response. CCL19 and CXCL12 overexpressed in various tumors, which activate tumor proliferation related signaling pathway and stimulate angiogenesis on one hand, recruit immune cells infiltrating into cancerous foci and trigger tumor associated inflammation on the other. CCR7, one of G protein-coupled chemokine receptors, leads to alteration of cell skeleton rearrangement and cell migration by binding its ligand CCL19[1]. |
