Recombinant Human IP-10/CXCL10是具有促炎和抗血管生成特性的CXC趨化因子家族的成員。
Synonyms
rHuIP-10/CXCL10; C-X-C motif chemokine 10; Gamma-IP10; Mob-1 ; 重組人IP-10/CXCL10
Species
HumanSource
E. coli Accession
P02778 Gene ID
3627 Molecular Weight
Approximately 8.6 kDa AA Sequence
MVPLSRTVRC TCISISNQPV NPRSLEKLEI IPASQFCPRV EIIATMKKKG EKRCLNPESK AIKNLLKAVS KEMSKRSP Biological Activity
The ED50 is <0.2 μg/mL as measured by HUVEC cells, corresponding to a specific activity of >5.0 × 103 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 50 mM Tris, pH 8.0. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human IP-10/CXCL10 (rHuIP-10/CXCL10) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human IP-10/CXCL10 (rHuIP-10/CXCL10) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CXCL10 binds CXCR3 receptor to induce chemotaxis, apoptosis, cell growth and angiostasis. Alterations in CXCL10 expression levels have been associated with inflammatory diseases including infectious diseases, immune dysfunction and tumor development. CXCL10 is also recognized as a biomarker that predicts severity of various diseases[1]. |
