Recombinant Human Interleukin-31是一種新型輔助T細胞衍生的細胞因子，在過敏性皮膚炎癥和特應(yīng)性皮炎中發(fā)揮重要作用。
Synonyms
rHuIL-31; IL31 ; 重組人白細胞介素-31
Species
HumanSource
E. coli Accession
Q6EBC2 Gene ID
386653 Molecular Weight
Approximately 15.8 kDa AA Sequence
SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T Biological Activity
The ED50 is <5 ng/mL as measured by human U-87 MG cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, pH 7.4. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-31 (rHuIL-31) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Interleukin-31 (rHuIL-31) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin-31 (IL-31), which is preferentially produced by T helper type 2 cells. IL-31 signals through a receptor composed of IL-31 receptor A and oncostatin M receptor. IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases[1]. Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin[2]. |
