Recombinant Human Growth Hormone 是一種多肽激素，可刺激生長、細(xì)胞繁殖和細(xì)胞再生，能用于治療兒童生長障礙。
Synonyms
rHuGH; Somatotropin; GH-N; GH1 ; 重組人生長激素
Species
HumanSource
E. coli Accession
P01241 Gene ID
2688 Molecular Weight
Approximately 22.1 kDa AA Sequence
FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV QCRSVEGSCG F Biological Activity
The ED50 is <0.5 ng/mL as measured by rat Nb2-11 lymphoma cells, corresponding to a specific activity of >2.0 × 106 units/mg. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Growth Hormone (rHuGH) to 100 μg/mL using ddH2O. Storage & Stability
Lyophilized recombinant Human Growth Hormone (rHuGH) is stored at -20°C. After reconstitution, it is stable at 4°C for 2 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Recombinant Human Growth Hormone is a peptide hormone that stimulates growth, cell reproduction, and cell regeneration, which can be used for the treatment of growth disorders in children[1]. Growth Hormone is a stress hormone that stimulates production of IGF-1 and raises the concentration of glucose and free fatty acids[2]. Growth Hormone exerts some of its effects by binding to receptors on target cells, where it activates the MAPK/ERK pathway[3]. |
