Recombinant Mouse Interleukin-22 通過(guò)保護(hù)腸干細(xì)胞免受免疫介導(dǎo)的組織損傷從而在上皮再生和抑制慢性炎癥反應(yīng)中起重要作用。
Synonyms
rMuIL-22; Cytokine Zcyto 18; IL-TIF
Species
MouseSource
E. coli Accession
Q9JJY9 Gene ID
50929 Molecular Weight
Approximately 16.8 kDa AA Sequence
LPVNTRCKLE VSNFQQPYIV NRTFMLAKEA SLADNNTDVR LIGEKLFRGV SAKDQCYLMK QVLNFTLEDV LLPQSDRFQP YMQEVVPFLT KLSNQLSSCH ISGDDQNIQK NVRRLKETVK KLGESGEIKA IGELDLLFMS LRNACV Biological Activity
The ED50 is <0.5 ng/mL as measured by Colo205 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Murine Interleukin-22 (rMuIL-22) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Murine Interleukin-22 (rMuIL-22) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines, expressed predominantly by subsets of innate lymphoid cells (ILCs) and activated T cells, including T helper 1 (TH1) cells, TH17 cells and TH22 cells. IL-22 can be recognized by a heterodimeric receptor complex that consists of two transmembrane subunits: IL-22R1 and IL-10R2. The binding of IL-22 to its receptor activates the JAK/STAT and MAPK signaling pathway, resulting in gene expression or repression. Since the IL-10R2 is shared by five cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) and is widely expressed in most cells, the expression of the IL-22R1 determines whether a cell is the target of IL-22. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation[1]. |
