| Recombinant Mouse Interleukin-13, His (CHO-expressed) 是一種 CHO 細(xì)胞來(lái)源的重要細(xì)胞因子，是一種多功能細(xì)胞因子，其主要作用是減少炎癥反應(yīng)。 Synonyms
rMuIL-13, His; P600
Species
Mouse Source
E. coli Accession
P20109 Gene ID
16163 Molecular Weight
Approximately 14 kDa AA Sequence
PVPRSVSLPL TLKELIEELS NITQDQTPLC NGSMVWSVDL AAGGFCVALD SLTNISNCNA IYRTQRILHG LCNRKAPTTV SSLPDTKIEV AHFITKLLSY TKQLFRHGPF HHHHHH Biological Activity
The ED50 is <20 ng/mL as measured by human TF-1 cells. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Murine Interleukin-13, His (CHO-expressed) (rMuIL-13, His) to 100 μg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Murine Interleukin-13, His (CHO-expressed) (rMuIL-13, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin (IL)-13 plays a pivotal role in the pathogenesis of allergic asthma. Passive administration of its monoclonal antibody or soluble receptor to block overproduced IL-13 has been proven to be effective in controlling airway allergic responses in animal models, but these approaches have disadvantages of short half-lives, high costs, and possible adverse effects. IL-13 induces the gene expression of Ca2+-activating chloride channel, stimulates the differentiation of epithelial cells, and promotes mucin gene expression and release. IL-13 plays a key role in the pathogenesis of asthma[1]. |
