Recombinant Human Interleukin-22 來源于 E. coli，是一種參與免疫應(yīng)答的細(xì)胞因子。
Synonyms
rHuIL-22; Cytokine Zcyto 18; IL-TIF
Species
HumanSource
E. coli Accession
Q9GZX6 Gene ID
50616 Molecular Weight
Approximately 16.9 kDa AA Sequence
MAPISSHCRL DKSNFQQPYI TNRTFMLAKE ASLADNNTDV RLIGEKLFHG VSMSERCYLM KQVLNFTLEE VLFPQSDRFQ PYMQEVVPFL ARLSNRLSTC HIEGDDLHIQ RNVQKLKDTV KKLGESGEIK AIGELDLLFM SLRNACI Biological Activity
The ED50 is <1 ng/mL as measured by COLO 205 (human colon carcinoma cells). Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Interleukin-22 (rHuIL-22) to 100 μg/mL using ddH2O or PBS. Storage & Stability
Lyophilized recombinant Human Interleukin-22 (rHuIL-22) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant humanIL-22 (hIL-22) is found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. IL-22 is a member of interleukin-10 family of cytokines, which also includes IL-19, IL-20, and IL-24 in addition to IL-10 and a number of its viral homologs[1]. |
