Recombinant Human Insulin-like Growth Factor-Binding Protein 5 是一種獨(dú)特的胰島素樣生長(zhǎng)因子結(jié)合蛋白，能夠調(diào)節(jié)胰島素樣生長(zhǎng)因子的活動(dòng)，刺激成骨細(xì)胞增殖。
Synonyms
rHuIGF-BP5; IBP-5 ; 重組人胰島素樣生長(zhǎng)因子結(jié)合蛋白 5
Species
HumanSource
CHO Accession
P24593 Gene ID
3488 Molecular Weight
Approximately 28.3 kDa AA Sequence
LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI CWCVDKYGMK LP Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, 150mM NaCl, pH 6.2. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstituted the lyophilized Human Insulin-like Growth Factor-Binding Protein 5 (rHuIGF-BP5) in ddH2O at 100 μg/mL. Storage & Stability
Lyophilized recombinant Human Insulin-like Growth Factor-Binding Protein 5 (rHuIGF-BP5) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 weeks or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Insulin-like Growth Factor-Binding Proteins (IGFBPs) modulate the actions of secreted insulin-like growth facts (IGFs) by binding to them and increase the IGF halflife in the extracellular milieu and circulation by sequestering them in this bound form. IGFBPs either enhance or inhibit IGF actions on target cells; the individual IGFBPs either inhibit or potentiate IGF effects on osteoblasts in bone. Human Insulin-like Growth Factor-Binding Protein 5 (rhIGFBP-5) is a unique and most abundant IGFBP stored in bone, having a high specific binding affinity for hydroxyapatite and extracellular matrix proteins, therefore fixing it and its bound IGFs within bone. rhIGFBP-5 consistently stimulates osteoblast cell proliferation in vitro, thus increasing the number of osteoblasts[1]. |
