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| 貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
| JD1227179006 | IRS-1 Phospho (pY896) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【產(chǎn)品類型】Rabbit Monoclonal IgG 【反應特異性】Human , Mouse , Rat 【克隆 ID】EP260Y 【用途】WB 【產(chǎn)品性狀】 【陽性對照】 【產(chǎn)品濃度】 【細胞定位】 【抗原分子量】170 kDa |
| 質(zhì)量標準： | 【產(chǎn)品介紹】Insulin recept o r substrates (IRS), the maj o r intracellular substrates of the insulin recept o r (IR), are adapt o r proteins that transduce signals from the IR to downstream effect o r s that are imp o r tant f o r the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosph o r ylated on multiple tyrosine residues. Once phosph o r ylated, IRS proteins bind a n d activate Grb-2, SHP2 a n d the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulat o r s of IR a n d the insulin-like growth fact o r -1 recept o r . Disruption of IRS-1 causes growth retardation a n d insulin resistance associated with hypertension, hypertriglyceridemia, a n d impaired endothelium-dependent vascular relaxation (4-5) WB: 1:500,000 A. Western blot analysis on 293 cell lysates |
