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貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
JD1227177831 | Gelsolin Rabbit Antibody | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
性狀: | 【反應特異性】Human 【克隆 ID】EP1940Y 【用途】WB , IHC 【抗原分子量】90 kDa |
質(zhì)量標準: | 【產(chǎn)品介紹】Gelsolin is a large a n d complex actin-binding protein that belongs to actin-severing gelsolin/villin super family. Gelsolin is a regulat o r of actin filament assembly a n d disassembly a n d consists of six homologous subdomains (S1-S6). When C-terminal tail (S6) is bound to calcium ion, it straightens a n d exposes actin binding sites located on S2s helices, leading to Gelsolin actin-serving activity (1). Gelsolin is inhibited by phosphatidylinositol (4,5)-bisphosphate (PIP2), where PIP2 will bind to S1, S2, a n d S3 sites. Gelsolin is involved in podosome f o r mation a n d has been linked to inhibition of apoptosis by preventing release of cytochrome C (2).
B. Immunohistochemical analysis of paraffin-embedded |