4007787550
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| 貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
| JD1227177780 | FAK Phospho (pY576) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應特異性】Human , Mouse , Rat 【克隆 ID】EP1987Y 【用途】WB , FC 【抗原分子量】125 kDa |
| 質(zhì)量標準： | 【產(chǎn)品介紹】Focal adhesion kinase (FAK) is a non-recept o r protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation a n d apoptosis (1). FAK is composed of a central catalytic domain flanked by large N- a n d C-terminal regions. FAK is activated by phosph o r ylation at tyrosine 397 in response to integrin clustering which can be induced by cell adhesion o r antibody cross-linking o r via G-protein-coupled recept o r (GPCR) occupancy by lig a n d s such as bombesin o r lysophosphatidic acid (2-3). Phosph o r ylation of FAK Tyr-397 c r e a t e s a binding site f o r Src-family kinases, a n d phosph o r ylation of FAK Tyr-576/Tyr-577 in the kinase domain activation loop enhances catalytic activity (4). Increased FAK expression has been c o r related with the enhanced motility a n d invasiveness of human tum o r cells, as well as with promoting increased cell proliferation (5).
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