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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫存 |
| JD1227177742 | EGFR | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Human , Mouse , Rat 【克隆 ID】E114 【用途】WB , IHC , ICC , IP 【抗原分子量】170-180 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】Epidermal growth fact o r recept o r (EGFR) is a 170 kDa transmembrane glycoprotein recept o r tyrosine kinase that, activated by epidermal growth fact o r (EGF), affects cell growth a n d differentiation (1). Binding of EGF o r TGF alpha to EGFR activates tyrosine kinase activity of the recept o r (2). Phosph o r ylation of Tyr 992, Tyr 1068 a n d Tyr 1086 is required f o r conf o r mational change in the C-terminal of EGFR (3). Autophosph o r ylation of Tyr 992 c r e a t e s a binding site f o r the phospholipase C-gamma (PLC-gamma) SH2 domain, inducing downstream signaling (4).
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