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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫(kù)存 |
| JD1227177694 | Cytokeratin 8 | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Human 【克隆 ID】EP1628Y 【用途】WB , IHC , ICC , FC , IP 【抗原分子量】52 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】Keratins, the intermediate filament proteins of epithelial cells, connect to desmosomes, the cell-cell adhesion structures at the surface membrane. Among the various intermediate filament (IF) proteins, cytokeratin 8 (CK8) is especially remarkable as it is produced early in embryogenesis, is the only type-II CK occurring in many simple epithelial cells, a n d can also be synthesized in certain non-epithelial cells (1). Keratin 8 a n d 18 (CK8/18) are the maj o r keratin pair in simple-type epithelia, as found in the liver, pancreas, a n d intestine (2). While K8/K18 are essential f o r maintaining structural integrity, there is accumulating evidence indicating that they also exert non-mechanical functions. It has been rep o r ted that K8/K18-free hepatocytes from K8-null mice are m o r e sensitive to Fas-mediated apoptosis, in line with an increased Fas density at the cell surface a n d an altered c-Flip regulation of the anti-apoptotic ERK1/2 signaling pathway (3).
A. Western blot analysis on A431 cell lysate using B. Immunohistochemical analysis of paraffin-embedded |
