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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫存 |
| JD1227177650 | Chk1 (CHEK1) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Human 【克隆 ID】EPR3952 【用途】WB 【抗原分子量】56kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】Chk1 is a serine/threonine-protein kinase required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA (1). It is regulated by Atr and plays an important role in embryonic development and tumor suppression (2). The activated Chk1 triggers the G2/M checkpoint, which arrests the cells in G2 to allow them to repair their DNA (3). The inhibition of Chk1 kinase results in the abrogation of the G2/M checkpoint and leads to cell death (3). Chk1 is activated in response to replication blocks and genotoxic stress, via phosphorylation of serines 317 and 345 (4). Activated Chk1 can bind to, phosphorylate (at serine 216), and inactivate cdc25c (4, 5).
WB WB: 1:1,000 - 10,000 Human Products Data Western blot analysis on (A) Jurkat (B) K562, (C) MCF-7, Specificity A synthetic peptide corresponding to residues in human |
| 貯存： | Storage Condition and Buffer Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), |
