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| 貨號(hào) | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫存 |
| JD1227177618 | CD209 | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Human 【克隆 ID】EPR5588 【用途】WB , IHC 【抗原分子量】50kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】CD209 is a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens, ranging from parasites to viruses with a large impact on public health. CD209 is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. CD209 is closely related in terms of both sequence and function to a neighboring protein L-SIGN. DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution (1).
WB, IHC WB: 1:1,000 - 10,000 Human *Species cross-reactivity is based on WB analysis.
Western blot analysis on (A) HACAT, (B) fetal skin,
Specificity A synthetic peptide corresponding to residues in human |
| 貯存： | Storage Condition and Buffer Store at -20 °C. Antibody buffer, 0.01% sodium azide, |
