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| 貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
| JD1227177591 | Calpain 2 (large subunit) (CAPN2) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應特異性】Human , Mouse , Rat 【克隆 ID】EPR5977 【用途】WB 【抗原分子量】80kDa |
| 質(zhì)量標準： | 【產(chǎn)品介紹】The calcium-activated protease calpain cleaves a variety of biologically important proteins and serves, therefore, as a key regulator of many cellular functions. Activation of both main isoforms, calpain 1 and calpain 2, was demonstrated previously in Alzheimer's disease. Calpain 2 could be directly involved in tau hyperphosphorylation by modulating protein kinase activities. Results provide evidence of the important role of the calpain proteolytic system in the pathogenesis of neurodegenerative diseases with tau neurofibrillary pathology (1). Calpain is intimately involved in modulating cell adhesion and migration. The two ubiquitous isoforms of this protease, calpain I and II, are considered to be cytosolic proteins that can translocate to both focal complexes/adhesions or the plasma membrane. Results reveal an increased association of calpain I, II, calpastatin, and the 30-kDa regulatory subunit with the endoplasmic reticulum and Golgi apparatus as evidenced by their position in the gradient relative to calnexin, Rab6, caveolin, and beta1 integrin after laminin stimulation. Further experiments established that calpain II colocalizes with phosphatidylinositol 4,5-bisphosphate (2).
WB WB: 1:1,000 - 10,000 Human, Mouse, Rat *Species cross-reactivity is based on WB analysis.
Western blot analysis on (A) PC-3, (B) HeLa, (C) A431,
A synthetic peptide corresponding to residues in |
| 貯存： | Storage Condition and Buffer Store at -20° C. Buffer: Antibody buffer, sodium |
