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| 貨號 | 品名 | 規(guī)格 | 包裝 | 單價 | 貨期 | 庫存 |
| JD1227177582 | Btk Phospho (pY551) | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應特異性】Human 【克隆 ID】EP267Y 【用途】WB , ICC 【抗原分子量】74 kDa |
| 質(zhì)量標準： | 【產(chǎn)品介紹】Btk (Bruton tyrosine kinase also known as BPK o r ATK) is a member of the TEC family of non-recept o r protein tyrosine kinase which includes Bmx, Itk a n d TEC. Btk is composed of a pleckstrin domain, an SH3 a n d SH2 domain, a catalytic kinase domain a n d a TEC homology domain (1). BTK plays a crucial role in B cell activation a n d development (2). Similar to Etk-TNFR2 interaction, Btk interacts with Fas, a member of the TNFR family involved in apoptosis in a lig a n d -independent manner (3) Btk can be activated through intramolecular autophosph o r ylation at tyrosine 551 a n d that Btk autophosph o r ylation is required f o r Btk catalytic functions (4). Mutations in the Btk gene have been linked to severe developmental blocks in human B-cell ontogeny leading to X-linked agammaglobulinemia (XLA). Patients with this disease are unusually prone to bacterial infection but not to viral infection (5).
A. Western blot analysis of anti-Btk phospho (pY551) |
