4007787550
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| 貨號 | 品名 | 規(guī)格 | 包裝 | 單價(jià) | 貨期 | 庫存 |
| JD1227177565 | Beclin-1 | -- | 100ul | 0元 | 現(xiàn)貨 | 3天 |
| 性狀： | 【反應(yīng)特異性】Human 【克隆 ID】EPR1733Y 【用途】WB , IHC , ICC , IP 【抗原分子量】52 kDa |
| 質(zhì)量標(biāo)準(zhǔn)： | 【產(chǎn)品介紹】The Beclin-1 (BECN1) gene encodes a 60-kDa coiled-coil protein that interacts with the prototypic apoptosis inhibit o r Bcl-2 (1). Beclin-1 promotes autophagy in autophagy-defective yeast with a targeted disruption of agp6/vps30, a n d in human MCF7 breast carcinoma cells. The autophagy-promoting activity of Beclin-1 in MCF7 cells is associated with inhibition of MCF7 cellular proliferation, in vitro clonigenicity a n d tum o r igenesis. Endogenous Beclin-1 protein expression is frequently low in human breast epithelial carcinoma cell lines a n d tissue, but is expressed ubiquitously at high levels in n o r mal breast epithelia (2). It has also been shown that Beclin 1 contains a leucine-rich nuclear exp o r t signal motif raising the possibility that its autophagy a n d / o r tum o r suppress o r function may require regulated, CRM1-dependent, nucleocytoplasmic transp o r t (3).
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